Clarisse Brígido’s research focuses on plant–microbe interactions in the rhizosphere and endosphere, with particular emphasis on: (i) elucidating the molecular mechanisms underlying beneficial plant–microbe associations; (ii) understanding the factors that shape the structure and composition of soil and plant-associated microbial communities; and (iii) assessing the potential of synthetic microbial communities (SynComs) to protect plants against biotic and abiotic stresses. Ultimately, her work aims to support the development of ecological and sustainable agricultural practices that enhance crop productivity on marginal soils.